REVIEW PAPER
Impact of genetic polymorphisms and gene-environment interactions assesing health efects of environmental and occupational exposure to lead
1
Pracownia Toksykologii Genetycznej, Instytut Medycyny Pracy i Zdrowia Środowiskowego w Sosnowcu,
Kierownik Pracowni: dr n. med. Natalia Pawlas
2
Pracownia Audiologii i Hałasu, Instytut Medycyny Pracy i Zdrowia Środowiskowego w Sosnowcu,
Kierownik Pracowni: dr hab. n. med. Krystyna Pawlas
3
Katedra i Zakład Higieny, Akademia Medyczna we Wrocławiu, Kierownik Katedry: dr hab. n. med. Krystyna Pawlas
Corresponding author
Natalia Pawlas
Pracownia Toksykologii Genetycznej Instytut Medycyny Pracy i Zdrowia Środowiskowego ul. Kościelna 13, 41-200 Sosnowiec
Pracownia Toksykologii Genetycznej Instytut Medycyny Pracy i Zdrowia Środowiskowego ul. Kościelna 13, 41-200 Sosnowiec
Med Srod. 2010;13(4):75–80
KEYWORDS
ABSTRACT
Health effects of exposure to xenobiotics, e.g. lead, differ between individuals. They are mainly influenced by xenobiotics’ concentration, however genetic polymorphisms may play a role in the interindividual variation. There is a number of reports indicating the influence of polymorphisms in the genes of δ-aminolevulinic acid dehydratase (ALAD), the vitamin D receptor (VDR), endothelial nitric oxide synthase (eNOS) on blood lead concentration in lead-exposed workers and environmentally exposed children.
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