Plasma Methylarginines, non-conventional risk factors of coronary-artery disease among subjects exposed and non-exposed to tobacco smoke
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Instytut Medycyny Pracy i Zdrowia Środowiskowego, Sosnowiec. Dyrektor: dr Piotr Z. Brewczyński
Zakład Opieki Zdrowotnej, Laboratorium Centralne, Olkusz. Dyrektor: lek. med. Jerzy Niewiara
Zakład Chemii Ogólnej i Nieorganicznej, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej, Śląski Uniwersytet Medyczny, Sosnowiec. Kierownik: dr hab. Andrzej Sobczak
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Andrzej Sobczak   

Zakład Szkodliwości Chemicznych i Toksykologii Genetycznej Instytut Medycyny Pracy i Zdrowia Środowiskowego ul. Kościelna 13, 41-200 Sosnowiec,
Med Srod. 2010;13(4):65-74
The role of methylated derivatives of arginine in cardiovascular diseases has been studied for over a decade. The reason for this are their biological characteristics. Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide synthase (NOS) and nowadays it is recognized as an independent risk factor of coronary artery disease. Application of symmetric dimethylarginine (SDMA) may be practical and useful for identifying subjects from early stage of renal disease and determining their risk of cardiovascular diseases. The first part of the paper shows biosynthesis and catabolism of methylarginines, the following part discusses their association with cardiovascular diseases and correlation between homocysteine plasma level. The third part of the paper is a review of studies that have evaluated the impact of tobacco smoke on ADMA and SDMA.
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