Effect of selected environmental factors on development of non-small cell lung cancer
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Regionalne Centrum Naukowo-Technologiczne, Polska
Corresponding author
Kacper Szafraniec   

Regionalne Centrum Naukowo-Technologiczne, Podzamcze 45, 25-636, Chęciny, Polska
Med Srod. 2024;27(2):46-50
Introduction and objective:
Cancer is one of the major health problems today. In Poland, mortality due to cancer remains at 260 deaths per 100,000 population per year, and lung cancer accounts for the highest number of cancer deaths in men and women. Non-small cell lung cancer (NSCLC) accounts for about 85% of lung cancer cases. The purpose of this review is to examine the effects of relevant environmental factors, such as smoking tobacco products, arsenic, beta-carotene, bisphenol A and atmospheric aerosols with a diameter smaller than 2.5 μm on the carcinogenesis of non-small cell lung cancer. By analyzing exposure to these substances, the study aims to highlight the need to reduce plastic production and seek alternatives to environmentally harmful human activities, including fuel combustion. The review article is based on a systematic analysis of scientific research in the field of non-small cell lung cancer. Existing research on environmental factors affecting the development of NSCLC was analyzed.

Abbreviated description of the state of knowledge:
Analysis of the incidence of NSCLC has revealed the importance of conducting research on environmental factors. This is emphasized by findings showing that smoking tobacco products, beta-carotene supplementation, and exposure to PM 2.5, bisphenol A and arsenic increase the risk of metastatic potential. Arsenic in the form of nitric trioxide (ATO) may also have beneficial effects. ATO supply reduces the proliferation of gefitinib-resistant NSCLC tumour cells and inhibits EGFR kinase activity.

Advances in knowledge of NSCLC factors are leading to therapeutic discoveries and emphasize the need for prevention of risk factors.

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