PL EN
PRACA POGLĄDOWA
 
SŁOWA KLUCZOWE
DZIEDZINY
STRESZCZENIE
Wprowadzenie i cel:
Choroba afektywna dwubiegunowa (ChAD) jest przewlekłym zaburzeniem psychicznym związanym ze znacznym upośledzeniem funkcjonowania psychospołecznego i przedwczesną umieralnością z powodu chorób współistniejących oraz znacznego odsetka dokonanych samobójstw. Niestety, wyniki dostępnych metod leczenia tej choroby nie są zadowalające. Poszukuje się zatem nowych terapii. Ostatnio szczególną uwagę zwrócono na nutraceutyki, a zwłaszcza na Wielonienasycone Kwasy Tłuszczowe Omega-3 (n-3 PUFAs), które mogą być pomocne w leczeniu wspomagającym zaburzeń psychicznych. Celem tego narracyjnego przeglądu literatury jest ukazanie roli PUFAs w patogenezie ChAD oraz przedstawienie wyników dotychczas przeprowadzonych badań oceniających wpływ suplementacji n-3 PUFAs na przebieg kliniczny ChAD.

Materiał i metody:
W tym celu w styczniu i lutym 2024 roku przeszukano internetowe bazy danych pod kątem odpowiednich artykułów oryginalnych i poglądowych z ostatnich 15 lat. Używano do tego następujących słów kluczowych: „bipolar disorder”, „cardiovascular risk”, „mental disorders”, „omega-3 fatty acids”, „polyunsaturated fatty acids”, „remission”, „treatment”, przy czym wykluczono z przeglądu teksty w języku innym niż angielski. Aby zapewnić odpowiednią jakość artykułu, zastosowano wytyczne the Scale for the Assessment of Narrative Review Articles.

Opis stanu wiedzy:
Istnieje niewiele badań oceniających znaczenie n-3 PUFAs w terapii ChAD. Wydaje się jednak, że suplementacja nimi może przynieść istotne korzyści kliniczne w ostrej fazie leczenia epizodu depresyjnego w przebiegu ChAD, utrzymaniu remisji i redukcji kardiometabolicznych czynników ryzyka.

Podsumowanie:
Wyniki dotychczas przeprowadzonych badań należy traktować jako uzasadnienie dalszych analiz w tym obszarze. Potwierdzenie skuteczności n-3 PUFAs w terapii ChAD wydaje się istotne dla oceny zasadności ich szerokiego stosowania w codziennej praktyce klinicznej.


Introduction and objective:
Bipolar Disorder (BD) is a chronic mental condition associated with significant impairment of psychosocial functioning and premature mortality due to somatic comorbidities, as well as high rates of completed suicides. Unfortunately, results of currently available methods of treatment are unsatisfactory. Thus, new therapeutic solutions are sought. Recently, particular attention has been paid to the use of nutraceuticals, especially Omega-3 Polyunsaturated Fatty Acids (n-3 PUFAs), as an adjunctive treatment in various mental disorders. The aim of the review is to show the role of PUFAs in the pathogenesis of BD, and present results of already conducted studies investigating n-3 PUFAs supplementation effects on the BD clinical course.

Materials and Method:
Internet scientific bases were searched throughout January and February 2024 for the relevant to this topic literature from the past 15 years, using keywords: “bipolar disorder”, “cardiovascular risk”, “mental disorders”, “omega-3 fatty acids”, “polyunsaturated fatty acids”, “remission”, “treatment”. Original and review articles were included. Manuscripts in other language than English were excluded from the search. To assess the proper quality of this manuscript, the Scale for the Assessment of Narrative Review Articles were used.

Brief description of the state of knowledge:
There is lack of research assessing the importance of n-3 PUFAs in the treatment of BD. However, it seems that their supplementation may bring significant benefits in the acute phase of depression episode treatment, remission maintenance and reduction in cardiometabolic risk factors.

Summary:
Results of already conducted studies should be treated as a rationale for future research. It is highly recommended to confirm the n-3 PUFAs efficiency in the BD treatment, to justify their widespread use in everyday clinical practice.

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