Carbon monoxide – poison or potential therapeutic agent?
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Katedra Biologii Medycznej i Badań Translacyjnych, Wydział Medyczny, Wyższa Szkoła Informatyki i Zarządzania w Rzeszowie
Zakład Biologii Molekularnej i Badań Translacyjnych, Instytut Medycyny Wsi im. Witolda Chodźki w Lublinie
Centrum Radiobiologii i Dozymetrii Biologicznej, Instytut Chemii i Techniki Jądrowej w Warszawie
Corresponding author
Lucyna Kapka-Skrzypczak   

Wyższa Szkoła Informatyki i Zarządzania w Rzeszowie Wydział Medyczny Katedra Biologii Medycznej i Badań Translacyjnych ul. Sucharskiego 2, 35-225 Rzeszów
Med Srod. 2016;19(4):59-69
Carbon monoxide, a low molecular gaseous mediator with pleiotropic activity, arises as a result of heme degradation in reaction catalyzed by heme oxygenase. There are a variety of scientific reports confirming the participation of carbon monoxide and heme oxygenase in protection against cellular stress. It has been shown that in biological systems, CO can display anti-inflammatory, anti-proliferative and anti-apoptotic effect. A better understanding of the function of this molecule has led to its use as a potential therapeutic agent in diseases associated with neurological, immune and vascular systems and transplantology. The aim of this study was to present the role of carbon monoxide in modulation of cellular processes, with particular consideration of potential application in pharmacotherapy
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