Telomere Length – a New Biomarker in Medicine
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Instytut Medycyny Pracy i Zdrowia Środowiskowego, Zakład Szkodliwości Chemicznych i Toksykologii Genetycznej w Sosnowcu, Kierownik Zakładu: prof. dr hab. n. med. A. Sobczak
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Agnieszka Kozłowska   

Zakład Szkodliwości Chemicznych i Toksykologii Genetycznej Pracownia Toksykologii Genetycznej Instytut Medycyny Pracy i Zdrowia Środowiskowego ul. Kościelna 13; 41-200 Sosnowiec tel. 32 6341194; fax. 32 266 11 24
Med Srod. 2015;18(4):7-13
A number of xenobiotics in the environment and workplace influences on our health and life. Biomarkers are tools for measuring such exposures and their effects in the organism. Nowadays, telomere length, epigenetic changes, mutations and changes in gene expression pattern have become new molecular biomarkers. Telomeres play the role of molecular clock, which influences on expectancy of cell life and thus aging, the formation of damages, development diseases and carcinogenesis. The telomere length depends on mechanisms of replication and the activity of telomerase. Telomere length is currently used as a biomarker of susceptibility and/or exposure. This paper describes the role of telomere length as a biomarker of aging cells, oxidative stress, a marker of many diseases including cancer, and as a marker of environmental and occupational exposure.
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