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Importance of gut microbiome in Alzheimer's disease
 
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Collegium Medicum, Uniwersytet Jana Kochanowskiego w Kielcach, Polska
 
These authors had equal contribution to this work
 
 
Corresponding author
Małgorzata Agnieszka Wojtania   

Collegium Medicum, Uniwersytet Jana Kochanowskiego w Kielcach, al. IX Wieków Kielc 19a, 25-516 Kielce, Kielce, Polska
 
 
 
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ABSTRACT
Introduction and objective:
Alzheimer’s disease is the most common cause of dementia in the general population worldwide. At present, about 40 million people suffer from this disease and statistics predict that the number of patients will increase to over 100 million within 30 years. This is a serious problem in the healthcare system. Recently, researchers have shown increased interest in identifying protective factors against developing Alzheimer’s disease. This will help reduce the financial costs associated with the treatment of this disease. A relationship was observed between the intestinal microbiome and the risk of Alzheimer’s disease. The aim of this article is to provide information about this relationship based on the most recent scientific achievements.

Abbreviated description of the state of knowledge:
Disturbance of the interspecies balance in the intestinal microflora results in an increased risk of Alzheimer’s disease. This could be explained by inflammation and remodelling of brain blood vessels. Examination of the composition of intestinal microflora in stools might be helpful in the diagnosis of dementia. A new look at the intestinal microbiota in the development of Alzheimer’s disease has enabled alternative therapeutic options, including the supply of probiotics, prebiotics and synbiotics, which exert a positive effect on the intestinal bacterial flora.

Summary:
Despite numerous studies, information concerning intestinal microflora is still not used in daily clinical practice to diagnose Alzheimer’s disease. Further observations of gut microbiota are necessary. Perhaps in the future, expanding knowledge about the role of diet in the course of Alzheimer’s disease will revolutionize the treatment and prevention of this disease.

 
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