REVIEW PAPER
The role of a diet including flaxseed in modifying risk factors for metabolic and cardiovascular diseases – literature review
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1
Faculty of Medicine, Wrocław Medical University, Wrocław, Poland
2
Internship, Healthcare Complex, Nysa, Poland
3
Internship, Jan Mikulicz-Radecki University Hospital, Wrocław, Poland
4
Internship, Copernicus Hospital, Gdańsk, Poland
These authors had equal contribution to this work
Corresponding author
Oliwia Biegańska
Wydział Lekarski, Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Ludwika Pasteura 1, 50-367, Wrocław, Polska
KEYWORDS
TOPICS
ABSTRACT
Introduction and objective:
Flaxseed is known for its wide range of health benefits. The aim of this literature review is to gather current scientific evidence regarding the effects of flaxseed consumption on risk factors for metabolic and cardiovascular diseases, such as blood pressure, lipid profile, glucose and insulin metabolism, and body weight.
Brief description of the state of knowledge:
Research indicates that flaxseed can lower both systolic and diastolic blood pressure, affecting peripheral as well as central measurements. It also appears to improve the lipid profile by reducing total cholesterol, LDL- (including small dense LDL), VLDL-, and non-HDL cholesterol, as well as triglycerides. Additionally, it decreases the total cholesterol to HDL ratio, as well as the LDL to HDL ratio. Flaxseed consumption may also raise HDL cholesterol levels. Its positive effects extend to glucose and insulin metabolism – lowering fasting blood glucose and glycated haemoglobin levels, reducing insulin resistance, increasing insulin sensitivity, and improving post-meal blood sugar control. Including flaxseed in the diet might also help reduce body weight, BMI, waist and hip circumference, waist-to-hip ratio, and body fat mass. Furthermore, it may increase adiponectin levels.
Summary:
Flaxseed has beneficial effects on blood pressure, lipid profile, glucose and insulin metabolism, and body weight. These benefits suggest that flaxseed may represent a valuable component of the daily diet supporting metabolic and cardiovascular health.
REFERENCES (45)
1.
Parikh M, Maddaford TG, Austria JA, et al. Dietary Flaxseed as a Strategy for Improving Human Health. Nutrients. 2019 May 25;11(5):1171.
2.
Hodson L, Crowe FL, McLachlan KJ, et al. Effect of supplementation with flaxseed oil and different doses of fish oil for 2 weeks on plasma phosphatidylcholine fatty acids in young women. Eur J Clin Nutr. 2018 June;72(6):832–40.
3.
Ahmadniay Motlagh H, Aalipanah E, Mazidi M, et al. Effect of flaxseed consumption on central obesity, serum lipids, and adiponectin level in overweight or obese women: A randomised controlled clinical trial. Int J Clin Pract. 2021 Oct;75(10):e14592.
4.
Sun J, Bai H, Ma J, et al. Effects of flaxseed supplementation on functional constipation and quality of life in a Chinese population: A randomized trial. Asia Pac J Clin Nutr. 2020;29(1):61–7.
5.
Soltanian N, Janghorbani M. Effect of flaxseed or psyllium vs. placebo on management of constipation, weight, glycemia, and lipids: A randomized trial in constipated patients with type 2 diabetes. Clin Nutr ESPEN. 2019 Feb;29:41–8.
6.
Haidari F, Banaei-Jahromi N, Zakerkish M, et al. The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trial. Nutr J. 2020 Jan 24;19(1):8.
7.
Mirmasoumi G, Fazilati M, Foroozanfard F, et al. The Effects of Flaxseed Oil Omega-3 Fatty Acids Supplementation on Metabolic Status of Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Exp Clin Endocrinol Diabetes Off J Ger Soc Endocrinol Ger Diabetes Assoc. 2018 Apr;126(4):222–8.
8.
Khandouzi N, Zahedmehr A, Mohammadzadeh A, et al. Effect of flaxseed consumption on flow-mediated dilation and inflammatory biomarkers in patients with coronary artery disease: a randomized controlled trial. Eur J Clin Nutr. 2019 Feb;73(2):258–65.
9.
Morshedzadeh N, Shahrokh S, Chaleshi V, et al. The effects of flaxseed supplementation on gene expression and inflammation in ulcerative colitis patients: An open-labelled randomised controlled trial. Int J Clin Pract. 2021 May;75(5):e14035.
10.
Jamilian M, Tabassi Z, Reiner Ž, et al. The effects of n-3 fatty acids from flaxseed oil on genetic and metabolic profiles in patients with gestational diabetes mellitus: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2020 Apr 14;123(7):792–9.
11.
Yari Z, Rahimlou M, Poustchi H, et al. Flaxseed supplementation improves anthropometric measurements, metabolic, and inflammatory biomarkers in overweight and obese adults. Int J Vitam Nutr Res. 2019 Mar 7;92(3–4):161–8.
12.
Raygan F, Taghizadeh M, Mirhosseini N, et al. A comparison between the effects of flaxseed oil and fish oil supplementation on cardiovascular health in type 2 diabetic patients with coronary heart disease: A randomized, double-blinded, placebo-controlled trial. Phytother Res. 2019 July;33(7):1943–51.
13.
Khandouzi N, Zahedmehr A, Asadian S, et al. Effects of olive oil and flaxseed consumption in a healthy diet on endothelial function, plasma lipids and inflammatory factors of patients with coronary heart disease: a randomized clinical trial. Coron Artery Dis. 2023 Aug 1;34(5):332–40.
14.
Tian Y, Zhou Y, Liao W, et al. Flaxseed powder supplementation in non-alcoholic fatty liver disease: a randomized controlled clinical trial. Food Funct. 2025 Feb 17;16(4):1389–406.
15.
Yari Z, Cheraghpour M, Alavian SM, et al. The efficacy of flaxseed and hesperidin on non-alcoholic fatty liver disease: an open-labeled randomized controlled trial. Eur J Clin Nutr. 2021 Jan;75(1):99–111.
16.
Rezaei S, Sasani MR, Akhlaghi M, et al. Flaxseed oil in the context of a weight loss programme ameliorates fatty liver grade in patients with non-alcoholic fatty liver disease: a randomised double-blind controlled trial. Br J Nutr. 2020 May 14;123(9):994–1002.
17.
Jiang X, Wang Y, Tang H, et al. Effect of light fasting diet therapy on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome combined with infertility. Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol. 2025 Dec;41(1):2458084.
18.
Yari Z, Cheraghpour M, Hekmatdoost A. Flaxseed and/or hesperidin supplementation in metabolic syndrome: an open-labeled randomized controlled trial. Eur J Nutr. 2021 Feb;60(1):287–98.
19.
Yari Z, Rahimlou M, Poustchi H, et al. Flaxseed Supplementation in Metabolic Syndrome Management: A Pilot Randomized, Open-labeled, Controlled Study. Phytother Res PTR. 2016 Aug;30(8):1339–44.
20.
Toulabi T, Yarahmadi M, Goudarzi F, et al. Effects of flaxseed on blood pressure, body mass index, and total cholesterol in hypertensive patients: A randomized clinical trial. Explore N Y N. 2022;18(4):438–45.
21.
Akrami A, Nikaein F, Babajafari S, et al. Comparison of the effects of flaxseed oil and sunflower seed oil consumption on serum glucose, lipid profile, blood pressure, and lipid peroxidation in patients with metabolic syndrome. J Clin Lipidol. 2018;12(1):70–7.
22.
Morshedzadeh N, Shahrokh S, Aghdaei HA, et al. Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis. Complement Ther Med. 2019 Oct;46:36–43.
23.
Di Y, Jones J, Mansell K, et al. Influence of Flaxseed Lignan Supplementation to Older Adults on Biochemical and Functional Outcome Measures of Inflammation. J Am Coll Nutr. 2017;36(8):646–53.
24.
Machado AM, de Paula H, Cardoso LD, et al. Effects of brown and golden flaxseed on the lipid profile, glycemia, inflammatory biomarkers, blood pressure and body composition in overweight adolescents. Nutr Burbank Los Angel Cty Calif. 2015 Jan;31(1):90–6.
25.
Caligiuri SPB, Rodriguez-Leyva D, Aukema HM, et al. Dietary Flaxseed Reduces Central Aortic Blood Pressure Without Cardiac Involvement but Through Changes in Plasma Oxylipins. Hypertens Dallas Tex 1979. 2016 Oct;68(4):1031–8.
26.
Kawakami Y, Yamanaka-Okumura H, Naniwa-Kuroki Y, et al. Flaxseed oil intake reduces serum small dense low-density lipoprotein concentrations in Japanese men: a randomized, double blind, crossover study. Nutr J. 2015 Apr 21;14:39.
27.
Dittrich M, Jahreis G, Bothor K, et al. Benefits of foods supplemented with vegetable oils rich in α-linolenic, stearidonic or docosahexaenoic acid in hypertriglyceridemic subjects: a double-blind, randomized, controlled trail. Eur J Nutr. 2015 Sept;54(6):881–93.
28.
Bongartz U, Hochmann U, Grube B, et al. Flaxseed Mucilage (IQP-LU-104) Reduces Body Weight in Overweight and Moderately Obese Individuals in a 12-week, Three-Arm, Double-Blind, Randomized, and Placebo-Controlled Clinical Study. Obes Facts. 2022;15(3):395–404.
29.
López-Toledo S, Pineda De la Cruz MC, Gutiérrez-Hurtado IA, et al. Flaxseed Improves Glucose and Lipid Metabolism in Mexican Subjects with Type 2 Diabetes: A Parallel Randomized Clinical Trial. Nutrients. 2025 Feb 17;17(4):709.
30.
Edel AL, Rodriguez-Leyva D, Maddaford TG, et al. Dietary flaxseed independently lowers circulating cholesterol and lowers it beyond the effects of cholesterol-lowering medications alone in patients with peripheral artery disease. J Nutr. 2015 Apr;145(4):749–57.
31.
Kanikowska D, Malińska A, Mickiewicz A, et al. Effect of Flaxseed (Linum usitatissimum L.) Supplementation on Vascular Endothelial Cell Morphology and Function in Patients with Dyslipidaemia-A Preliminary Observation. Nutrients. 2022 July 13;14(14):2879.
32.
Torkan M, Entezari MH, Siavash M. Effect of flaxseed on blood lipid level in hyperlipidemic patients. Rev Recent Clin Trials. 2015;10(1):61–7.
33.
Morshedzadeh N, Rahimlou M, Shahrokh S, et al. The effects of flaxseed supplementation on metabolic syndrome parameters, insulin resistance and inflammation in ulcerative colitis patients: An open-labeled randomized controlled trial. Phytother Res PTR. 2021 July;35(7):3781–91.
34.
Sant’Ana CT, Amorim AD de, Gava AP, et al. Brown and golden flaxseed reduce intestinal permeability and endotoxemia, and improve the lipid profile in perimenopausal overweight women. Int J Food Sci Nutr. 2022 Sept;73(6):829–40.
35.
Kuang X, Li K, Shi Y, et al. Gene-diet interaction in response to defatted flaxseed flour supplementation on obesity-related traits in Chinese overweight and obese adults: A randomized controlled trial. Nutr Burbank Los Angel Cty Calif. 2023 Jan;105:111870.
36.
Avelino APA, Oliveira GMM, Ferreira CCD, et al. Additive effect of linseed oil supplementation on the lipid profiles of older adults. Clin Interv Aging. 2015;10:1679–85.
37.
Kuang X, Kong Y, Hu X, et al. Defatted flaxseed flour improves weight loss and lipid profile in overweight and obese adults: a randomized controlled trial. Food Funct. 2020 Sept 23;11(9):8237–47.
38.
Moreira FD, Reis CEG, Welker AF, et al. Acute Flaxseed Intake Reduces Postprandial Glycemia in Subjects with Type 2 Diabetes: A Randomized Crossover Clinical Trial. Nutrients. 2022 Sept 10;14(18):3736.
39.
Repin N, Kay BA, Cui SW, et al. Investigation of mechanisms involved in postprandial glycemia and insulinemia attenuation with dietary fibre consumption. Food Funct. 2017 June 1;8(6):2142–54.
40.
Vuksan V, Choleva L, Jovanovski E, et al. Comparison of flax (Linum usitatissimum) and Salba-chia (Salvia hispanica L.) seeds on postprandial glycemia and satiety in healthy individuals: a randomized, controlled, crossover study. Eur J Clin Nutr. 2017 Feb;71(2):234–8.
41.
Almehmadi A, Lightowler H, Chohan M, et al. The effect of a split portion of flaxseed on 24-h blood glucose response. Eur J Nutr. 2021 Apr;60(3):1363–73.
42.
Pieters DJ, Zock PL, Fuchs D, et al. Effect of α -linolenic acid on 24-h ambulatory blood pressure in untreated high-normal and stage I hypertensive subjects. Br J Nutr. 2019 Jan 28;121(2):155–63.
43.
Joris PJ, Draijer R, Fuchs D, et al. Effect of α-linolenic acid on vascular function and metabolic risk markers during the fasting and postprandial phase: A randomized placebo-controlled trial in untreated (pre-)hypertensive individuals. Clin Nutr Edinb Scotl. 2020 Aug;39(8):2413–9.
44.
Barre DE, Mizier-Barre KA, Griscti O. Various apolipoprotein E genotypes relate to responsiveness to flaxseed lignan complex in older persons with type 2 diabetes mellitus. Endocr Regul. 2024 Jan 1;58(1):220–4.
45.
Lim TL, Pietrofesa RA, Arguiri E, et al. Phase II Trial of Flaxseed to Prevent Acute Complications After Chemoradiation for Lung Cancer. J Altern Complement Med N Y N. 2021 Oct;27(10):824–31.