REVIEW PAPER
The Trojan Effect: Would prevention of air pollution be a better solution to Alzheimer’s disease than developing medication?
| 1 | MSc Pharmaceutics, School of Pharmacy, University College London, Brunswick Square, London, WC1N 1AX; |
| 2 | PhD, Senior Research Associate at The Bartlett School of Environment Energy and Resources, Institute for Environmental Design and Engineering University College London, Upper Woburn Place, London |
| 3 | Now at: Public Health England, Air Quality & Public Health Group, Environmental Hazards and Emergencies Dept., Centre for Radiation, Chemical and Environmental Hazards, Harwell Science and Innovation Campus, Chilton, Oxon, OX11 0RQ |
CORRESPONDING AUTHOR
Hyun Jee Han
MSc Pharmaceutics, School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX;
MSc Pharmaceutics, School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX;
Med Srod. 2018;21(3):50–67
KEYWORDS
air pollutionPM2.5WHO GuidelineneuroinflammationAlzheimer’s diseaseeco-politicsglobal trendrecapitulation model
ABSTRACT
Emerging evidence is showing that air pollution is achronic source of neuroinflammation, which has a causal relationship with Alzheimer ’s disease (AD), an increa-singly common and devastating illness in elderly populations. A report on the association between PM from air
pollution and AD provided scientific explanations for the mechanisms driving air pollution-induced CNS pathology, which stimulates calls for action at the political level. This scoping review considers the range of recognised and novel approaches associated with AD, highlighting how neurobiology, sociology of medicine and eco-politics collaborate to generate the interdisciplinary picture of the effects of PM on this malignancy. Such holistic approaches will allow this field to move forward and could lead to an improvement of actionable policies.
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