Exploring the role of anthropogenic air pollutants in the pathogenesis of acne
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Provincial Specialist Hospital No. 5, St. Barbara in Sosnowiec, Poland
Independent Public Health Care Facility, Municipal Hospital Complex in Chorzów, Poland
University Clinical Hospital of the Military Medical Academy – Central Veterans’ Hospital, Łódź, Poland
These authors had equal contribution to this work
Corresponding author
Martyna Kubicka - Figiel   

Wojewódzki Szpital Specjalistyczny nr 5 im. św. Barbary w Sosnowcu, Plac Medyków 1, 41-200, Sosnowiec, Polska
Introduction and objective:
Increasing global urbanization has led to significant atmospheric air pollution. Airborne pollutants, including PM, O3, CO, NOx, and SO2, exert detrimental effects on the entire body, contributing to various skin diseases. The aim of this study was to review the literature on the effects of selected air pollutants on the development or exacerbation of acne vulgaris, and to elucidate the mechanisms responsible.

Brief description of the state of knowledge:
Existing studies offer insights into the substantial impact of anthropogenic air pollution on the onset and aggravation of acne. Pollution particles affect the skin on various levels, compromising the protective sebum layer, triggering oxidative stress and inflammatory responses, and instigating noteworthy alterations in skin cell structures.

Reduction in the prevailing levels of anthropogenic air pollutants is crucial for curbing the incidence of acne and enhancing public health. This skin condition detrimentally impacts the quality of life and the mental well-being of those affected, particularly in an era that champions an idealized appearance. The incorporation of substances with antioxidant and anti-inflammatory properties, fortifying the skin barrier, could also prove beneficial. Further research is imperative to deepen our understanding of the relationship between air pollution and acne, as well as to explore effective strategies for shielding the skin from pollution.

Zaenglein AL, Pathy AL, Schlosser BJ, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016;74(5):945–973.e33.
Dréno B, Pécastaings S, Corvec S, et al. Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates. J Eur Acad Dermatol Venereol. 2018;32(S2):5–14.
World Health Organization. Types of pollutants [internet]. Available from: (access 2023.12.09).
Li X, An SJ, Liu XL, et al. The association between short-term air pollution exposure and post-adolescent acne: the evidence from a time series analysis in Xi’an, China 2021. Clinic Cosmet Investig Dermatol. 2021;723–731.
El Haddad C, Gerbaka NE, Hallit S, et al. Association between exposure to ambient air pollution and occurrence of inflammatory acne in the adult population. BMC Pub Health. 2021;21(1):1–14.
Liu W, Pan X, Vierkotter A, et al. A time-series study of the effect of air pollution on outpatient visits for acne vulgaris in Beijing. Skin Pharmacol Physiol. 2018;31(2):107–113.
Krutmann J, Liu W, Li L, et al. Pollution and skin: from epidemiological and mechanistic studies to clinical implications. J Dermatol Sci. 2014;76:163–168.
Lefebvre MA, Pham DM, Boussouira B, et al. Evaluation of the impact of urban pollution on the quality of skin: a multicentre study in Mexico. Int J Cosmet Sci. 2015;37(3):329–338.
Lefebvre MA, Pham DM, Boussouira B, et al. Consequences of urban pollution upon skin status. A controlled study in Shanghai area. Int J Cosmet Sci. 2016;38:217–223.
Butman JL, Thomson RJ, Geiger FM. Unanticipated hydrophobicity increases of squalene and human skin oil films upon ozone exposure. J Phys Chem B. 2022;126(45):9417–9423.
Danby FW. Ductal hypoxia in acne: is it the missing link between comedogenesis and inflammation? J Am Acad Dermatol. 2014;70(5):948–949.
Mancebo SE, Wang SQ. Recognizing the impact of ambient air pollution on skin health. J Eur Acad Dermatol Venereol. 2015;29: 2326–2332.
Alam J, Yadav VK, Yadav KK, et al. Recent advances in methods for the recovery of carbon nanominerals and polyaromatic hydrocarbons from coal fly ash and their emerging applications. Crystals. 2021;11(2):88.
Leung MHY, Tong X, Bastien P, et al. Changes of the human skin microbiota upon chronic exposure to polycyclic aromatic hydrocarbon pollutants. Microbiome. 2020;8(1):1–17.
Sun L, Wang H, Huang J, et al. A cross-sectional cohort study on the skin microbiota in patients with different acne duration. Exp Dermatol. 2023;32(12):2102–2111.
Valacchi G, Sticozzi C, Pecorelli A, et al. Cutaneous responses to environmental stressors. Ann N Y Acad Sci. 2012;1271(1):75–81.
Ferrara F, Prieux R, Woodby B, et al. Inflammasome Activation in Pollution-Induced Skin Conditions. Plast Reconst Surg. 2021;147(1S–2):15S–24S.
Rathinam VAK, Chan FK. Inflammasome, Inflammation, and Tissue Homeostasis. Trends Mol Med. 2018;24:304–318.
ElAttar Y, Mourad B, Alngomy HA, et al. Study of interleukin-1 beta expression in acne vulgaris and acne scars. J Cosmet Dermatol. 2022;21(10):4864–4870.
Ferrara F, Pambianchi E, Pecorelli A, et al. Redox regulation of cutaneous inflammasome by ozone exposure. Free Radic Biol Med. 2020;152: 561–570.
Li ZJ, Choi DK, Sohn KC, et al. Propionibacterium acnes activates the NLRP3 inflammasome in human sebocytes. J Invest Dermatol. 2014;134:2747–2756.
Zi Y, Jiang B, He C, et al. Lentinan inhibits oxidative stress and inflammatory cytokine production induced by benzo(a)pyrene in human keratinocytes. J Cosmet Dermatol. 2020;19(2):502–507.
Park SY, Byun EJ, Lee JD, et al. Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter (PM10) on Human Dermal Fibroblasts. Int J Mol Sci. 2018;19(8):2254.
Suvanprakorn P, Tongyen T, Prakhongcheep O, et al. Establishment of an Anti-acne Vulgaris Evaluation Method Based on TLR2 and TLR4-mediated Interleukin-8 Production. In Vivo. 2019;33(6):1929–1934.
Chen X, Min S, Chen C, et al. Influence of RETN, IL-1, and IL-6 gene polymorphisms on the risk of acne vulgaris in the Chinese population. J Cosmet Dermat. 2022;21(10):4965–4973.
Pambianchi E, Hagenberg Z, Pecorelli A, et al. Tension as a key factor in skin responses to pollution. Sci Rep. 2023;13(1):16013.
Ahn EK, Yoon HK, Jee BK, et al. COX-2 expression and inflammatory effects by diesel exhaust particles in vitro and in vivo. Toxicol Lett. 2008;176(3):178–187.
Vogel CFA, VanWinkle LS, Esser C, et al. The aryl hydrocarbon receptor as a target of environmental stressors – Implications for pollution mediated stress and inflammatory responses. Redox Biol. 2020; 34:11530.
Tsuji G, Takahara M, Uchi H, et al. An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway. J Dermatol Sci. 2011;62:42–49.
Lee CW, Lin ZC, Hu SC, et al. Urban particulate matter down-regulates filaggrin via COX2 expression/PGE2 production leading to skin barrier dysfunction. Sci Rep. 2016;6(1):27995.
Hashem NM, Hosny A, Abdelrahman AA, et al. Antimicrobial activities encountered by sulfur nanoparticles combating Staphylococcal species harboring sccmecA recovered from acne vulgaris AIMS Microbiol. 2021;7(4):481.
Gruber JV, Holtz R. In vitro expression of NLRP inflammasome-induced active Caspase-1 expression in normal human epidermal keratinocytes (NHEK) by various exogenous threats and subsequent inhibition by naturally derived ingredient blends. J Inflamm Res. 2019;12:219–230.
Chang YP, Ka SM, Hsu WH, et al. Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy. J Cell Physiol. 2015;230:1567–1579.
Kong F, Ye B, Cao J, et al. Curcumin represses NLRP3 inflammasome activation via TLR4/MyD88/NF-?B and P2X7R signaling in PMA-induced macrophages. Front Pharmacol. 2016;7:369.
Yang G, Lee HE, Yeon SH, et al. Licochalcone A attenuates acne symptoms mediated by suppression of NLRP3 inflammasome. Phytother Res. 2018;32:2551–2559.
Guo M, An F, Yu H, et al. Comparative effects of schisandrin A, B, and C on propionibacterium acnes-induced, NLRP3 inflammasome activation-medi- ated IL-1ß secretion and pyroptosis. Biomed Pharmacother. 2017;96:129–136.
Yang G, Lee SJ, Kang HC, et al. Repurposing auranofin, an antirheumatic gold compound, to treat acne vulgaris by targeting the NLRP3 inflammasome. Biomol Ther. 2020;28(5):437–442.
Liu S, Luo XH, Liu YF, et al. Emodin exhibits anti-acne potential by inhibiting cell growth, lipogenesis, and inflammation in human SZ95 sebocytes. Sci Rep. 2023;13(1):21576.
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