Antituberculous drugs from seas and oceans
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Instytut Medycyny Wsi im. Witolda Chodźki w Lublinie, Zakład Biologii Molekularnej i Badań Translacyjnych Kierownik Zakładu Biologii Molekularnej i Badań Translacyjnych: dr hab. n. med. Lucyna Kapka-Skrzypczak, prof. IMW
Wydział Medyczny, Wyższa Szkoła Informatyki i Zarządzania w Rzeszowie, Katedra Biologii Medycznej i Badań Translacyjnych
Żaneta Polak   

Zakład Biologii Molekularnej i Badań Translacyjnych Instytut Medycyny Wsi im. Witolda Chodźki ul. Jaczewskiego 2, 20-090 Lublin tel. 81 71 84 584
Med Srod. 2017;20(4):7–13
In spite of the remarkable developments in medicine over the last century, the problem of tuberculosis in some parts of the world remains unresolved. Africa and South East Asia are endangered areas, where the population is high, and hygiene and access to medications are insufficient. The occurrence of Mycobacteria resistant to standard drugs is a serious clinical problem. Synthesizing completely new compounds that have antimycobacterial activity takes years and generates costs, so researchers are returning to natural resources. The main direction of the search for new potentially antituberculous substances are plants, but salt water is becoming increasingly important as well. The depths of the seas and oceans offer many unexplored substances that, as it turns out, have interesting antimicrobial properties. New research methods in silico greatly expedite the process of identifying compounds and their properties. The use of discovered substances as scaffolds of new compounds significantly improves the efficiency of the process and enhances the pharmacological properties of natural metabo-lites of marine organisms. This article summarizes the current knowledge of marine substances that could be potential antituberculous drugs.
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