RESEARCH PAPER
The combined effect of scutellaria baicalensis extract and coenzyme Q10 in oxidative stress induced by chromium compounds
 
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Katedra i Zakład Toksykologii Akademii Medycznej we Wrocławiu Kierownik Katedry Toksykologii: prof. dr hab. Anna Długosz
CORRESPONDING AUTHOR
Ewa Sawicka
53-417 Wrocław, ul. Traugutta 57/59 tel./fax +48 713 444 4375
 
Med Srod. 2010;13(1):72–77
 
KEYWORDS
ABSTRACT
Background:
The common use of antioxidants and its joint application brings the question whether they are useful in oxidative stress induced by the chemicals or whether they cause harmful interaction. Both Scutellaria baicalensis and CoQ10 are known as antioxidants, however one exogenous, the second endogenous. Chromium belongs equal to essential microelements and toxic factors. Therefore the aim of work was the evaluation joint effect of two examined antioxidants in exposure to chromium compounds.

Material and Methods:
The material was fresh blood obtained from healthy volunteers. The concentration of malondialdehyde (MDA) in erythrocytes was evaluated using Stock’s method. The activity of mixture of Antoxyd and coenzyme Q10 was tested after exposure to chromium III and VI at concentrations: 0,05; 0,5 and 1,0 μg/ml. Antioxidants were used in concentrations : 8,0; 20; 60 and 100 μg/ml.

Results:
The influence of coenzyme Q10 in exposure to chromium III and chromium VI was statistically insignificant, but CoQ10 given together with Antoxyd in all used concentration statistically significant decreased the level of MDA in erythrocytes exposed to chromium compounds (p<0,001).

Conclusions:
Application of both antioxidants has exerted synergistic action lowering MDA level, which was elevated after chromium. No harmful interactions in the examined sample between antioxidants and chromium ions were noted.

 
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