Free radicals in tobacco smoke – analytical approach and biomedical significance
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Zakład Szkodliwości Chemicznych i Toksykologii Genetycznej, Instytut Medycyny Pracy i Zdrowia Środowiskowego w Sosnowcu
Zakład Chemii Ogólnej i Nieorganicznej, Wydział Farmaceutyczny w Sosnowcu Śląski Uniwersytet Medyczny w Katowicach Kierownik Zakładu: prof. dr hab. n. med. A. Sobczak Dziekan Wydziału: dr hab. n. farm. S. Boryczka
Department of Health Behaviour Division of Cancer Prevention and Population Sciences Roswell Park Cancer Institute, Buffalo, USA prof. dr A. Hyland, PhD, dyrektor instytutu: prof. D. Trump, MD, FACP
Leon Kośmider
Instytut Medycyny Pracy i Zdrowia Środowiskowego ul. Kościelna 13, 41-200 Sosnowiec tel. 32 634 11 91
Med Srod. 2013;16(3):7–14
Free radicals, i.e. atoms or groups of atoms containing one or more unpaired electrons, are significant constituents of tobacco smoke that contribute to its toxic properties. Radicals are generated during complex pyrolysis and combustion reactions in burning a cigarette cone. It has been shown that some free radicals found in tobacco smoke have relatively long half-time life (over 5 mins). We have reviewed modern analytical methods used for identification and quantitative analysis of free radicals in tobacco smoke, particularly the electron paramagnetic resonance combined with a spin-trapping approach. We also discussed the role of free radicals in etiology of respiratory and cardiovascular conditions among smokers. Finally, we reviewed biochemical mechanisms of various pathological conditions, including disturbances in lipid peroxidation, activity modification of lecithin-cholesterol acyltransferase and level high density lipoprotein, hyperactivity to substance P, and inactivation of neutral endopeptidase, that are thought to be contributed by free radicals from tobacco smoke.
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