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The impact of tobacco smoke on women’s fertility
 
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Katedra Biotechnologii Zwierząt, Wydział Hodowli i Biologii Zwierząt, Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie. Kierownik katedry: prof. dr hab. D. Zięba-Przybylska
 
 
Corresponding author
Anna K. Wójtowicz   

ul. Rędzina 1b, 30-248 Kraków tel. (12) 429 75 47
 
 
Med Srod. 2015;18(2):11-16
 
KEYWORDS
ABSTRACT
Over the years, the regularity laws about smoking in public places have been more and more restrictive due to the growing awareness of health problems caused by smoking tobacco. Despite that, the global number of smokers is increasing. Men are still the majority of addicted people but the number of women smoking is also high. Among them are pregnant women, in which case, the negative health effects of tobacco smoke also affect the fetus. It is well known that active as well as passive smoking can lead to cardiovascular diseases, strokes, lung and laryngeal cancers and promotes atherosclerosis. Recently, there has been a growing scientific interest in dysfunction of endocrine system and fertility observed in smokers. Women addicted to smoking often have menstrual cycle disorders, ovulatory dysfunction and early menopause. In the case of pregnant women exposed to tobacco smoke, the risk of miscarriage or complication during the childbirth is higher. Harmful tobacco smoke components delivered to the maternal organism cause disruption of the placenta and abnormal fetus development.
 
REFERENCES (54)
1.
Murray C., Lopez A.: Alternative projections of mortality and disease by cause, 1990–2020: global burden of disease study. Lancet 1997; 349: 1498–1504.
 
2.
Sandler D., Everson R., Willcox A., Browder J.: Cancer risk in adulthood from early life exposure to parent’s smoking. Am J Public Health 1985; 75: 487–492.
 
3.
Stankus R., Menon P., Rando R., et al.: Cigarette smoke sensitive asthma: challenge studies. J Allergy Clin Immunol 1988; 82: 331–338.
 
4.
Strachan D., Jarvis M., Feyerabend C.: Passive smoking, salivary cotinine concentrations, and middle ear effusion in 7 year old children. Br Med J 1989; 298: 1549–1552.
 
5.
Ganesan S., Keating A.F.: Impact of 7,12-dimethylbenz[a]anthracene exposure on connexin gap junction proteins in cultured rat ovaries. Toxicol Appl Pharmacol 2014; 274: 209–214.
 
6.
Neal M.S., Mulligan Tuttle A.M., Casper R.F., Lagunov A., Foster W.G.: Aryl hydrocarbon receptor antagonists attenuate the deleterious effects of benzo[a]pyrene on isolated rat follicle development. Reprod BioMed Online 2010; 21: 100–108.
 
7.
Sadeu J.C., Foster W.G.: Effect of in vitro exposure to benzo[a]pyrene, a component of cigarette smoke, on folliculogenesis, steroidogenesis and oocyte nuclear maturation. Reprod Toxicol 2011; 31: 402–408.
 
8.
Grasseschi R.M., Ramaswamy R.B., Levine D.J., Klaassen C.D., Wesselius L.J.: Cadmium accumulation and detoxification by alveolar macrophages of cigarette smokers. Chest 2013; 124:1924–1928.
 
9.
Willett W.C., Green A., Stampfer M. J. et al.: Relative and absolute excess risks of coronary heart disease among women who smoke cigarettes. N Engl J Med 1987; 317: 1303–1309.
 
10.
Powell J.T.: Vascular damage from smoking: Disease mechanisms at the arterial wall. Vasc Med 1998; 3: 21–28.
 
11.
Edjoc R.K., Reid R.D., Sharma M., Fang J.: The prognostic effect of cigarette smoking on stroke severity, disability, length of stay in hospital, and mortality in a cohort with cerebrovascular disease. J Stroke Cerebrovasc Dis 2013; 22: 446–454.
 
12.
Weng W.C., Huang W.Y., Chien Y.Y. et al.: The impact of smoking on the severity of acute ischemic stroke. J Neurol Sci 2011; 308: 94–97.
 
13.
Underner M., Perriot J., Peiffer G., Meurice J.C.: Influence of tobacco smoking on the risk of developing asthma. Rev Mal Respir 2015; 32: 110–137.
 
14.
Siasos G., Tsigkou V., Kokkou E. et al.: Smoking and atherosclerosis: mechanisms of disease and new therapeutic approaches. Curr Med Chem 2014; 2: 3936–3948.
 
15.
Sasco A.J, Secretan M.B., Straif K.: Tobacco smoking and cancer: a brief review of recent epidemiological evidence. Lung Cancer 2004; 45: Suppl 2: S3–9.
 
16.
Raport z ogólnopolskiego badania ankietowego na temat postaw wobec palenia tytoniu, TNS Polska dla Głównego Inspektoratu Sanitarnego, Warszawa 2013.
 
17.
Czapiński J.: Nikotynizm w Polsce. Raport dla World Health Organisation, Warszawa 2011.
 
18.
Polańska K., Hanke W., Laudański T., Kalinka J.: Serum cotinine level as a biomarker of tobacco smoke exposure during pregnancy. Ginekol Pol 2007; 78: 796–801.
 
19.
Mlynarcikova A., Fickova M., Scsukova S.: Ovarian intrafollicular processes as a target for cigarette smoke components and selected environmental reproductive disruptors. Endocr Regul 2005; 39: 21–32.
 
20.
Caserta D., Bordi G., Di Segni N. i wsp: The influence of cigarette smoking on a population of infertile men and women. Arch Gynecol Obstet 2013; 287: 813–818.
 
21.
Whitcomb B.W., Bodach S.D., Mumford S.L. et al.: Ovarian function and cigarette smoking. Paediatr Perinat Epidemiol 2010; 24: 433–440.
 
22.
Miceli F., Minici F., Tropea A. et al.: Effects of nicotine on human luteal cells in vitro: a possible role on reproductive outcome for smoking women. Biol Reprod 2005; 72: 628–632.
 
23.
Vidal J.D., VandeVoort C.A., Marcus C.B. et al.: In vitro exposure to environmental tobacco smoke induces CYP1B1 expression in human luteinized granulosa cells. Reprod Toxicol 2006; 22: 731–737.
 
24.
Windham G.C., Mitchell P., Anderson M., Lasley B.L.: Cigarette smoking and effects on hormone function in premenopausal women. Environ Health Perspect 2005; 113: 1285–1290.
 
25.
Freour T., Masson D., Mirallie S. et al.: Active smoking compromises IVF outcome and affects ovarian reserve. Reprod Biomed Online 2008; 16: 96–102.
 
26.
Gruber I., Just A., Birner M., Losch A.: Effect of a woman’s smoking status on oocyte, zygote, and day 3 pre-embryo quality in in vitro fertilization and embryo transfer program. Fertil Steril 2008; 90: 1249–1252.
 
27.
Neal M.S., Hughes E.G., Holloway A.C., Foster W.G.: Side-stream smoking is equally as damaging as mainstream smoking on IVF outcomes. Hum Reprod 2005; 20: 2531–2535.
 
28.
Sadeu J.C., Foster W.G.: Cigarette smoke condensate exposure delays follicular development and function in a stage-dependent manner. Fertil Steril 2011a; 95: 2410–2417.
 
29.
Neal M.S., Zhu J., Holloway A.C., Foster W.G.: Follicle growth is inhibited by benzo-[a]-pyrene, at concentrations representative of human exposure, in an isolated rat follicle culture assay. Hum Reprod 2007; 22: 961–967.
 
30.
Nusbaum M.L., Gordon M., Nusbaum D. et al.: Smoke alarm: a review of the clinical impact of smoking on women. Prim Care Update Ob/Gyns 2000; 7: 207–214.
 
31.
Catsburg C., Kirsh V.A., Soskolne C.L. i wsp: Active cigarette smoking and the risk of breast cancer: a cohort study. Cancer Epidemiol 2014; 38: 376–381.
 
32.
Castelli W.P.: Cardiovascular disease: pathogenesis, epidemiology, and risk among users of oral contraceptives who smoke. Am J Obstet Gynecol 1999; Jun: S349–356.
 
33.
Bouyer J., Coste J., Shojaei T. et al.: Risk factors for ectopic pregnancy: a comprehensive analysis based on a large case control, population-based study in France. Am J Epidemiol 2003; 157: 185–194.
 
34.
Karaer A., Avsar F.A., Batioglu S.: Risk factors for ectopic pregnancy: a case-control study. Aust N Z J Obstet Gynaecol 2006; 46: 521–527.
 
35.
Ananth C.V., Smulian J.C., Vintzileos A.M.: Incidence of placental abruption in relation to cigarette smoking and hypertensive disorders during pregnancy: a meta – analysis of observational studies. Obstet Gynecol 1999; 93: 622–628.
 
36.
Windham G.C., Ekin E.P., Sawan S.H. et al.: Cigarette smoking and effects of menstrual function. Obstet Gynecol 1999; 93: 59–65.
 
37.
Hoffman H.J., Damus K., Hillman L., Krongrad E.: Risk factors for SIDS. Results of the National Institute of Child Health and Human Development SIDS Cooperative Epidemiological Study. Ann N Y Acad Sci 1988; 533: 13–30.
 
38.
Demir R., Demir A., Yinanc M.: Structural changes in placental barrier of smoking mother. A quantitative and ultrastructural study. Pathol Res Pract 1994; 190: 656–667.
 
39.
Laskowska – Klita T., Szymborski J., Chechłowska M. i wsp.: Nadtlenki lipidowe i wybrane parametry obrony przeciwutlenającej w łożysku i krwi pępowinowej noworodków matek palących w przebiegu ciąży. Badania własne. Med Wieku Rozw 2001; 5: 35–42.
 
40.
Piekoszowski W., Florek E., Kornacka M.K.: Level of cadmium and zinc in placenta of smoking women. Przegl Lek 2005;62: 1062–1066.
 
41.
Eskenazi B., Prehn A.W., Christianson R.E.: Passive and active maternal smoking as measured by serum cotinine: the effect on birthweight. Am. J. Public Health 1995; 85: 395–398.
 
42.
Haustein K.O.: Smoking cardiovascular diseases and possibilities for treating nicotine dependence. Wien Med Wochenschr 1999; 149: 19–24.
 
43.
Klesges L.M., Murray D.M., Brown J.E. et al.: Relations of cigarette smoking and dietary antioxidants with placental calcification. Am J Epidemiol 1998; 147: 127–135.
 
44.
Blake K., Gurrin L., Evanta S. et al.: Maternal cigarette smoking during pregnancy, low birth weight and subsequent blood pressure in early childhood. Early Hum Develop 2000; 57: 137–147.
 
45.
Brennan KA, Laugesen M, Truman P.: Whole tobacco smoke extracts to model tobacco dependence in animals. Neurosci Biobehav Rev 2014; 47: 53–69.
 
46.
Slatter T.L., Park L., Anderson K. et al.: Smoking during pregnancy causes double-strand DNA break damage to the placenta. Hum Pathol 2014; 45: 17–26.
 
47.
Gidding S., Morgan W., Perry C. et al.: Active and passive tobacco exposure: a serious pediatric health problem. AHA Medical/ Scientific Statement Special Report 1994; 2581–2590.
 
48.
Olds D., Henderson C., Tatelbaum R.: Intellectual impairment in children of women who smoke cigarettes during pregnancy. Pediatrics 1994; 93: 221–227.
 
49.
Szychta W., Skoczylas M., Laudański T.: Spożywanie alkoholu i palenie tytoniu przez kobiety w ciąży – przegląd badań. Perinatol Neonatol Ginek 2008; 1: 309–313.
 
50.
Machaalani R., Ghazavi E., Hinton T. et al.: Cigarette smoking during pregnancy regulates the expression of specific nicotinic acetylcholine receptor (nAChR) subunits in the human placenta. Toxicol Appl Pharmacol 2014; 276: 204–212.
 
51.
Cornelius M. D., Leech S. L., Goldschmidt L., Day N. L.: Prenatal tobacco exposure: Is it a risk factor for early tobacco experimentation? Nicotine Tob Res 2000; 2: 45–52.
 
52.
Shi M., Wheby G.L.: Review on genetic variants and maternal smoking in the etiology of oral clefts and other birth defects. Birth Defects Res 2008; 84: 16–29.
 
53.
Shino C.H., Klebanoff A., Berendes H.W.: Congenital malformations and maternal smoking during pregnancy. Teratology 1986; 34: 65–71.
 
54.
Baumert M.: Wpływ palenia papierosów przez ciężarne na rozwój płodu i noworodka. Przegląd Pediatryczny 2004; 2: 79–83.
 
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